Requirement of the serine at residue 329 for lipid raft recruitment of DNAM-1 (CD226)
نویسندگان
چکیده
منابع مشابه
Requirement of the serine at residue 329 for lipid raft recruitment of DNAM-1 (CD226).
Upon antigen recognition by the TCR, leukocyte function-associated antigen-1 (LFA-1) physically associates with the leukocyte adhesion molecule DNAM-1 (CD226), for which the serine phosphorylation at residue 329 (S329) of DNAM-1 plays a critical role. The TCR-mediated signal also induces the formation of the immunological synapse (IS), in which lipid raft-associated molecules, including LFA-1, ...
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15 صفحه اولAssociation of the CD226 (DNAM-1) Gly307Ser polymorphism with juvenile idiopathic arthritis
Background Recent genetic studies have reported an association of the Gly307Ser single nucleotide polymorphism (SNP) in the CD226 gene with susceptibility to multiple autoimmune diseases. CD226 or DNAM-1 is a type 1 membrane protein belonging to the Ig-superfamily and is involved in the adhesion and co-stimulation of T cells and NK cells. A trend towards association of this SNP with Juvenile Id...
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ژورنال
عنوان ژورنال: International Immunology
سال: 2005
ISSN: 1460-2377
DOI: 10.1093/intimm/dxh199